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. Author manuscript; available in PMC: 2009 May 27.
Published in final edited form as: Nature. 2008 Oct 26;456(7221):511–515. doi: 10.1038/nature07414

Figure 3. PDE5A inhibitor treatment improves exercised-induced vasomodulation and reduces exercise-induced edema in mdx mice.

Figure 3

a, Representative images of coronal Laser Doppler analysis of blood flow from mdx mice pre- and post-exercise (n=3), and b, mdx mice pre- and post-exercise + PDE5A inhibitor treatment (n=3). c, Representative Microfil® image of mdx + PDE5A inhibitor treatment quadriceps skeletal muscle arteries post-exercise (n=3, Scale bar = 100 μm). d-e, Representative MRI axial views of: d, mdx hind-limb muscles pre- and post-exercise (n=5) and e, hind-limb muscles post-exercise of mdx treated with PDE5A inhibitor before exercise (n=5). White arrowheads mark areas of increased water compartmentalization. f, Percent muscle edema area preand post-exercise and +/− PDE5A inhibitor treatment in mdx mice compared to that of wild-type. (wild-type and mdx n=3, mdx + PDE5A inhibitor n=5, error bars are s.e.m.)