CBD decreases TNF-α via activation of A2AAR in the retina. Male SD rats were pretreated before LPS injection with a single dose of CBD (1 mg/kg, i.p.) or vehicle. Thirty minutes later, rats were given vehicle, CPX (3 mg/kg, i.p), or ZM 241385 (ZM, 10 mg/kg, i.p.). Rats were treated with LPS (0.35 mg/kg, footpad) 1 h after CBD injection. Twenty-four hours after LPS treatment, rats were killed, and retina and vitreous were collected. TNF-α levels were determined by ELISA (n = 6). *, P < 0.05 compared with vehicle control; §, P > 0.05 compared with control and P < 0.05 compared with CBD alone (one-way ANOVA followed by the post hoc test (Fisher's PLSD).