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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Hepatol. 2008 Jun 30;49(5):821–830. doi: 10.1016/j.jhep.2008.05.025

Figure 3. Probiotics improve obesity and insulin resistance in HF diet mice via a NKT cell dependant manner.

Figure 3

Mice were treated the same as described in Figure 2. A) Animal weight. D) Glucose tolerance tests. (n=8/exp with triplicate experiments). In separate experiments, NKT cells were isolated from the livers of normal mice and then injected to recipient mice that had been on HF diet for 12 weeks (HF+NKT). Control HF mice received the same amount of splenic T cells (HF+T). The animals were then evaluated 4 days after adoptive transfer. B) Animal weight. E) Glucose tolerance tests. (n=6/exp with duplicated experiments). In addition, wild type (WT) and CD1d null (CD1dko) C57BL6 mice (not age and weight matched) were fed for 8 weeks on either ND or HF diets, and then some the HF diet mice were treated with probiotics (wt+HF+probiotics or CD1dko+HF+probiotics), and the other HF diet mice were treated with vehicle (wt+HF or CD1dko+HF) for an additional 4 weeks. ND diet mice all were fed ND diet continuously (CD1dko+ND). C) Animal weight change. F) Glucose tolerance tests. (n=6/exp with duplicated experiments). #p<0.05 vs ND, *p<0.05 vs HF. p=0.36 CD1dko+HF vs CD1dko+HF+probiotics.