Table 3.
Genes exhibiting decreased expression among two or more brain regions examined in the PGD2-treated rats (A) and in the CGS21680-treated rats (B).
| Table 3A. 8 genes are commonly downregulated by at least 50% in two or more brain regions in response to PGD2.
| |||
|---|---|---|---|
| Brain Regions | Probeset Name | Gene Name | Genbank # |
| BF and Cx | AF042714_at | Neurexophilin 4 (Nxph4) | AF042714 |
| U88036_at | Solute carrier family 21 (organic anion transporter), member 5 (Slc21a5) | U88036 | |
| BF and Hy | AJ001029_at | SRY-box containing gene 10 (Sox10) | AJ001029 |
| M59786_at | Calcium channel, voltage-dependent, alpha 1C subunit (Cacna1c) | M59786 | |
| X17012mRNA_ | Rat IGFII gene for insulin-like growth factor II. | X17012 | |
| Cx and Hy | AF081365_s_at | Potassium inwardly-rectifying channel, subfamily J, member 1 (Kcnj1) | AF081365 |
| AFFX-DapX-M_at | 26.7% identity to the Escherichia coli bifunctional biotin operon repressor | L38424 | |
| BF, Cx and Hy | X51992_at | Gamma-aminobutyric acid A receptor, alpha 5 (Gabra5) | X51992 |
| Table 3B. 20 distinct genes are commonly downregulated by at least 50% in two or more brain regions in response to CGS21680.
| |||
| Brain Regions | Probeset Name | Gene Name | Genbank # |
|
| |||
| BF and Cx | U16845_at | Neurotrimin (RNU16845) | U16845 |
| U73142_at | Mitogen activated protein kinase 14 (Mapk14) | U73142 | |
| X15468cds_at | Rat mRNA for GABA(A) receptor beta-3 subunit. | X15468 | |
| Z11548_at | Glutamate receptor, ionotropic, kainate 2 (Grik2) | Z11548 | |
| BF and Hy | AB016160_g_at | Gamma-aminobutyric acid (GABA) B receptor, 1 (Gabbr1) | AB016160 |
| M31076_at | Transforming growth factor alpha (Tgfa) | M31076 | |
| M32867_at | Potassium voltage gated channel, shaker related subfamily, member 4 (Kcna4) | M32867 | |
| rc_AA893870_g_at | EST197673 Normalized rat placenta; cDNA clone RPLAM86 3′ end, mRNA sequence. | AA893870 | |
| rc_AI235758_s_at | Protein kinase, cAMP dependent regulatory, type II beta (Prkar2b) | AI235758 | |
| S94371_g_at | GluR-4c; glutamate receptor subunit 4c | S94371 | |
| X12589cds_s_at | potassium channel protein (AA 1-495), voltage-dependent. | X12589 | |
| X14788_s_at | CAMP responsive element binding protein 1 (Creb1) | X14788 | |
| Cx and Hy | AF021935_at | Ser-Thr protein kinase related to the myotonic dystrophy protein kinase (Pk428) | AF021935 |
| M58040_at | Transferrin receptor (Tfrc) | M58040 | |
| M59980_s_at | Potassium voltage gated channel, Shal-related family, member 2 (Kcnd2) | M59980 | |
| rc_AA925246_at | Cathepsin K (Ctsk) | AA925246 | |
| S55933_i_at | GABAA receptor alpha 4 subunit [rats, mRNA, 1843 nt]. | S55933 | |
| S94371_at | GluR-4c; glutamate receptor subunit 4c {alternatively spliced}. | S94371 | |
| BF, Cx and Hy | X17012mRNA_s_at | Rat IGFII gene for insulin-like growth factor II. | X17012 |
| U88036_at | Solute carrier family 21 (organic anion transporter), member 5 (Slc21a5) | U88036 | |
| X51992_at | Gamma-aminobutyric acid A receptor, alpha 5 (Gabra5) | X51992 | |
Entries in bold type are commonly downregulated by both PGD2 and CGS21680 in at least two of the same brain regions.