Skip to main content
. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: J Immunol. 2008 Jun 1;180(11):7461–7470. doi: 10.4049/jimmunol.180.11.7461

FIGURE 2.

FIGURE 2

Comparison of D and JH gene segments and their RSS. VH, D1, D2, and JH gene segments in G1, G2, G3, G4, G5, G7, and G8 all span an area of <2 kb, as shown in Fig. 1. The heptamer/nonamer sequences are bolded, being 3′ of the VH flank, 5′ of the JH gene segment, and straddling D1 and D2. Splice signal in JH in lower case. The “12–23 rule” permits several kinds of rearrangement possibilities, but the most common observed in cDNA is VH to D1 to D2 to JH. Many RSS do not conform to the canonical sequence but all the functional genes rearrange. Among pseudogenes (ψ), recombination has been looked for and found in G2C. G6 and G8 can be transcribed and are potentially open to RAG action, but the cDNA sequences are nonrearranged.