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Corticosterone response to acute stress by footshock in early night (ZT15). WT mice displayed a significant induction of corticosterone in response to acute stress (baseline: 33.63±16.07 ng/ml, n=5; vs. stress: 201.30±17.16 ng/ml, n=5; P<0.01). A similar corticosterone response to acute stress was also observed in VIP KO mice (baseline: 13.14±6.49 ng/ml, n=3; vs. stress 243.00±35.39 ng/ml, n=6; P<0.05). Statistical significances were determined by non-parametric Mann-Whitney t-tests.
