Figure 7.

PCP2 accelerates the rising phase of light response of rod bipolar cells under strychnine and picrotoxin. A, Average current responses to a saturating flash intensity of 2.9 log photons μm⁻². The average holding current of the null cells was ∼10 pA larger than that of wild type (p < 0.05). VC, Voltage clamp. B, An expanded peak response showing the wild-type peak to be sharper than that of knock-out mouse both under Ames and under strychnine (Stry) and picrotoxin (PTX). The arrows point to the difference in the peak response. C, The time between stimulus onset and response peak (time to peak) was significantly shorter for wild-type than for null cells (Student's t test, *p < 0.05). Error bars indicate SEM.