Table 1.
Mutations that impair secondary lymphoid organ development.
| Mutation | Signalling pathway | Cells affected | mLNsa | pLNsb | PPsc | NALT | References |
|---|---|---|---|---|---|---|---|
| Lta−/− | LTβR | stroma | ±d | − | − | ±e | (21, 44, 45, 110) |
| Ltb−/− | LTβR | stroma | ± | − | − | ± | (21, 54, 110) |
| Ltbr−/− | LTβR | stroma | − | − | − | ± | (21, 55, 110) |
| Light−/− | LTβR | stroma | + | + | + | NDf | (57) |
| Light/Ltb−/− | LTβR | stroma | − | − | − | ND | (57) |
| Aly/aly | LTβR | stroma | − | − | − | ± | (21, 65, 110) |
| Il7ra−/− | IL-7R | LTi | + | + | − | ± | (15, 21, 34, 110) |
| Il2rg/rag−/− | IL-7R | LTi | + | + | − | − | (86) |
| Jak3−/− | IL-7R | LTi | + | + | − | ND | (15, 34) |
| Trance−/− | TRANCE-R | LTi | − | − | + | + | (35, 37, 110) |
| Rank−/− | TRANCE-R | LTi | − | − | + | ND | (36) |
| Traf6−/− | TRANCE-R | LTi | − | − | + | ND | (38) |
| Rorc−/− | LTi | − | − | − | + | (10, 19, 110) | |
| Id2−/− | LTi | − | − | − | − | (18, 21) | |
| Ikaros−/− | LTi | − | − | − | ND | (23) | |
| Cxcl13−/− | CXCR5 | LTi/B | − | − | − | ± | (40, 41) |
| Cxcr5−/− | CXCR5 | LTi/B | − | − | − | ND | (74) |
| Plt/plt | CCR7 | LTi/B/T | + | + | + | + | (40, 65) |
| Ccr7−/− | CCR7 | LTi/B/T | + | + | + | ND | (129) |
| Cxcl13/Ccl19/21−/− | CXCR5/CCR7 | LTi/B/T | − | − | − | ± | (40) |
| Ret−/− | RET | LTin | ND | ND | − | ND | (16) |
| Graf51/51 | RET | LTin | ND | ND | ± | ND | (16) |
a
mesenteric lymph nodes
b
peripheral lymph nodes
c
Peyer’s patches
d
small mLNS developed in a few mice
e
small, disorganized NALT developed
f
Not determined