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. Author manuscript; available in PMC: 2009 May 15.
Published in final edited form as: J Immunol. 2008 Nov 15;181(10):7073–7080. doi: 10.4049/jimmunol.181.10.7073

Figure 1. Low NK function of spleen cells from NOD and NOD congenic mice in spite of normal numbers of DX5+CD3− cells.

Figure 1

(A) Cytotoxicity mediated by total splenocytes from NOD (n = 16), B6 (n = 11), NOD.Idd3/5 (n = 11), NOD.Idd3/10/18 (n = 9), and NOD.Idd9 (n = 10) mice was tested using a 4 h 51Cr release assays. YAC-1 target cells were labelled with 51Cr and co-cultured with in vivo poly I:C stimulated splenocytes at an effector:target (E:T) ratio of 200:1. (B) Percentages of DX5+CD3− cells in the lymphocyte gate of total splenocytes analysed by flow cytometry. (C) MFI of CD69 on DX5+ cells with and without activation using in vivo poly I:C. P values were obtained by unpaired, two-tailed t tests, and refer to tests against NOD. ***, P < 0.001.