Table 2.
Qualitative comparisons of main retinal changes observed in rd1 and rd10 mutant mice, as a function of time. Data are from the present paper and from References quoted in the text.
| Mouse Strain | Mutation and inheritance | Degeneration features | Onset of rod degeneration | Recordable ERG Responses | Alterations in mGluR6 Distribution | Dendritic retraction in Rod Bipolar cells | Occurrence of Rod Bipolar & Horizontal cell death | Dendritic retraction in Cone Bipolar cells |
|---|---|---|---|---|---|---|---|---|
| rd1 | rod-specific PDE (β subunit) NONSENSE
Autosomal recessive |
rod-cone
center-to-periphery gradient |
P8 | P14-P16 | P18- | P10-
(possible arrest in growth) |
YES
(data available at P90 only) |
Detectable after P30 |
| rd10 | Rod-specific PDE (β subunit) MISSENSE
Autosomal recessive |
rod-cone
center-to-periphery gradient |
P18 | P14-P28 | P25- | P25-
(regression of fully developed dendrites) |
YES
(data available from P45 to 7 months) |
Best detected after P60 |