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. 2008 Dec 26;4(12):e1000249. doi: 10.1371/journal.pcbi.1000249

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Calzolari et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Letters indicate drugs and numbers indicate different doses of each drug. The root (level 0) is the control (no drugs), level 1 is composed of individual drug measurements (singles), level 2 is composed of combinations of two drugs (couples) and so on. The level corresponds to the size of the combination. Both this tree and the tree of Jelinek [14] contain repetitions.