Table 1.
Three different clinical scenarios in which EBV-related SMNs developed: patient summary. Dx = diagnosis. SMN = smooth muscle neoplasm. DOD = dead of disease. AWD = alive with disease. NED = no evidence of disease.
| # | Age at Dx (year) | Cause of immune dysregulation | Date of start of immune dysregulation | Time to SMN | Site | Treatmen | Status follow-up |
|---|---|---|---|---|---|---|---|
| 1 | 55M | Cadaveric renal transplant prednisone, cyclosporine, azathioprine, mycophenolate mofetil | 1994 | 8 years | Liver (caudate 14 cm); lung | Observation (declined systemic therapy) (7/02) | DOD 5 months |
|
| |||||||
| 2 | 18F | AIDS CD4 count = 8 | Birth | 11 years | Colon, chest, paraspinal/ vertebral, liver, gluteal, perigastric areas | Antiretrovirals doxorubicin, then dacarbazine (10/03) | AWD without progression, 5 years |
|
| |||||||
| 3 | 25F | Psoriasis, etanercept therapy | 20+ years, 8/04 | 20+ years, 5 months after etanercept started | Liver | Stopped immunosuppressives; hepatic resection (10/05) | NED, 3 years |