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Summary of the single nucleotide incorporation kinetic constants for HIV-RT at position n Km is in μm dGTP or ETV-TP. kcat is in min–1. Selectivity is defined as a ratio of kcat/Km for dGTP over kcat/Km for ETV-TP. S.D. was determined on the basis of at least three independent experiments.
|
Substrate
|
Selectivity
|
|||||
|---|---|---|---|---|---|---|
|
dGTP
|
ETV-TP
|
|||||
| kcat | Km | kcat/Km | kcat | Km | kcat/Km | |
| min–1 | μm | min–1 | μm | |||
| 0.51 ± 0.068 | 0.041 ± 0.0075 | 13 | 0.34 ± 0.11 | 0.45 ± 0.075 | 0.74 | 18 |
