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. 2008 Dec 5;283(49):33816–33825. doi: 10.1074/jbc.M807428200

FIGURE 6.

FIGURE 6.

Analysis of glycogen metabolizing enzymes and related proteins in old Epm2a–/– mice. Muscle or brain extracts from 9–12-month-old wild type (WT) and Epm2a–/– mice were analyzed. A, GS protein levels in the LSS and the LSP of muscle extracts. B, glycogen debranching enzyme (AGL) and branching enzyme (BE) protein levels in muscle extracts, and muscle PTG protein levels in the high speed centrifugation glycogen pellet. C, glycogenin protein levels in the LSP and the high speed pellets (HSP) of muscle treated or not with α-amylase. D, GS activity in LSS from muscle in the absence (white bars) or presence (black bars) of G6P. The corresponding activity ratio is shown. *, p < 0.05 (n = 3). E, GS activity in the LSP from muscle in the absence or presence of G6P. The corresponding activity ratio is shown. *, p < 0.05 (n = 3). F, GS protein levels in the LSS and the LSP of brain extracts. G, AGL and branching enzyme protein levels in brain extracts, and PTG protein levels in the high speed centrifugation glycogen pellet of brain extracts. H, GS activity in the LSS from brain. The activity ratio is shown (n = 3). I, GS activity in the LSP from brain. The activity ratio is shown (n = 3). KO, knock-out.