Table 2.

Bacterial inhibition and potentiation results for 2-aryl analogues of INF55 (2) with berberine in S. aureus. NP denotes no antibacterial potentiation. The inhibitor concentrations are the minimum for potentiation of berberine MIC by factors of 3.3 (K1758), 3.3 (8325-4), and 13.3 (K2378).

			MIC (µM) of inhibitor
			Δ norA K1758 plus berberine	WT 8325-4 plus berberine	NorA++ K2378 plus berberine
Compd	R1	R2
32	H	2′-CO2Me	NP	20	20
33	H	2′-CH2OH	NP	45	45
18	H	3′-CO2Me	40	5	10
19	H	3′-CH2OH	NP	45	45
22	H	4′-CO2Me	NP	20	40
23	H	4′-CH2OH	NP	22	45
225	NO2	H	0.63	1.3	1.3
34	NO2	2′-CO2Me	NP	34	NP
3513	NO2	2′-CH2OH	24	47	47
20	NO2	3′-CO2Me	0.51	1.0	1.0
21	NO2	3′-CH2OH	9	5	9
24	NO2	4′-CO2Me	NP	17	NP
25	NO2	4′-CH2OH	5	2	2