Table 2.
Ten highest linkage scores, by cohort and trait. Positions are given in centiMorgans according to the Marshfield map, Screening Set 9 (http://www2.marshfieldclinic.org/RESEARCH/GENETICS/sets/Set9ScreenFrames.htm). The physical locations, in parentheses, are given according to the UCSD Human genome browser build 35 (http://genome.ucsc.edu/).
BN-ARP | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
QTL | |||||||||||
OBS | MENAR | ANX | |||||||||
Chr | Position* | LOD | pval | Chr | Position | LOD | pval | Chr | Position | LOD | Pval |
7 | 21(7p21.3) | 1.558 | 0.004 | 10 | 36(10p13) | 2.899 | 0.00013 | 1 | 198(1q31.1) | 1.865 | 0.002 |
18 | 79(18q21.31) | 1.417 | 0.005 | 4 | 13(4p16.1) | 1.297 | 0.007 | 4 | 209(4q35.2) | 1.753 | 0.002 |
16 | 101(16q23.1) | 1.256 | 0.008 | 14 | 56(14q22.2) | 1.112 | 0.012 | 8 | 81(8q13.1) | 1.729 | 0.002 |
11 | 100(11q22.3) | 1.039 | 0.014 | 5 | 126(5q23.1) | 1.108 | 0.012 | 15 | 68(15q24.1) | 1.62 | 0.003 |
6 | 179(6q26) | 0.944 | 0.02 | 12 | 56(12q12) | 1.096 | 0.012 | 8 | 1(8p23.3) | 1.121 | 0.012 |
5 | 40(5p14.1) | 0.922 | 0.02 | 4 | 105(4q23) | 1.05 | 0.014 | 13 | 33(13q13.3) | 0.973 | 0.02 |
5 | 196(5q35.3) | 0.909 | 0.02 | 16 | 17(16p13.3) | 0.816 | 0.03 | 3 | 225(3q29) | 0.932 | 0.02 |
16 | 15(16p13.3) | 0.88 | 0.02 | 18 | 13(18p11.31) | 0.715 | 0.03 | 1 | 76(1p33) | 0.927 | 0.02 |
12 | 150(12q24.32) | 0.849 | 0.02 | 3 | 191(3q26.31) | 0.714 | 0.03 | 2 | 262(2q37.3) | 0.884 | 0.02 |
1 | 208(1q31.3) | 0.773 | 0.03 | 10 | 104(10q22.3) | 0.593 | 0.05 | 6 | 137(6q23.3) | 0.873 | 0.02 |
COVARIATE | |||||||||||
BMI | CM | OBF | |||||||||
Chr | Position | Eq LOD | pval | Chr | Position | Eq LOD | pval | Chr | Position | Eq LOD | pval |
14 | 54(14q22.2) | 2.983 | 0.00021 | 16 | 11(16p13.3) | 2.965 | 0.0002 | 14 | 54(14q22.2) | 2.965 | 0.00022 |
3 | 63(3p23) | 1.953 | 0.00271 | 14 | 56(14q22.2) | 2.965 | 0.00022 | 4 | 13(4p16.1) | 2.721 | 0.00033 |
10 | 34(10p13) | 1.869 | 0.00335 | 4 | 25(4p15.33) | 1.737 | 0.00468 | 10 | 36(10p13) | 2.168 | 0.00158 |
5 | 12(5p15.32) | 1.62 | 0.0063 | 8 | 66(8q11.23) | 1.697 | 0.00518 | 8 | 67(8q11.23) | 1.851 | 0.0035 |
3 | 23(3p26.1) | 1.578 | 0.00703 | 10 | 64(10p11.21) | 1.678 | 0.00544 | 16 | 11(16p13.3) | 1.745 | 0.00423 |
3 | 119(3q12.3) | 1.57 | 0.00717 | 10 | 38(10p13) | 1.445 | 0.00988 | 18 | 17(18p11.31) | 1.667 | 0.00559 |
8 | 77(8q12.1) | 1.177 | 0.01988 | 17 | 117(17q25.3) | 1.369 | 0.01203 | 5 | 152(5q31.3) | 1.457 | 0.00959 |
4 | 13(4p16.1) | 1.136 | 0.01988 | 6 | 73(6p12.3) | 1.209 | 0.01827 | 3 | 139(3q13.33) | 1.436 | 0.01011 |
4 | 96(4q21.23) | 1.114 | 0.0222 | 3 | 37(3p25.2) | 1.11 | 0.02377 | 5 | 22(5p15.2) | 1.342 | 0.01293 |
1 | 260(1q43) | 1 | 0.03186 | 5 | 150(5q31.3) | 1.078 | 0.02587 | 1 | 102(1p31.1) | 1.327 | 0.01342 |
AN-ARP | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
QTL | |||||||||||
OBS | MENAR | ANX | |||||||||
Chr | Position | LOD | pval | Chr | Position | LOD | pval | Chr | Position | LOD | pval |
6 | 129(6q23.1) | 1.774 | 0.002 | 14 | 63(14q23.1) | 1.437 | 0.005 | 9 | 52(9p21.3) | 1.821 | 0.002 |
1 | 206(1q31.1) | 1.549 | 0.004 | 21 | 58(21q22.3) | 1.377 | 0.006 | 9 | 88(9q21.33) | 1.65 | 0.003 |
6 | 153(6q25.2) | 1.052 | 0.014 | 4 | 111(4q25) | 1.326 | 0.007 | 6 | 127(6q23.1) | 0.922 | 0.02 |
12 | 25(12p13.2) | 0.78 | 0.03 | 10 | 175(10q26.3) | 1.037 | 0.014 | 2 | 4(2p25.3) | 0.748 | 0.03 |
2 | 134(2q14.3) | 0.73 | 0.03 | 20 | 45(20p12.1) | 1.032 | 0.015 | 14 | 115(14q32.13) | 0.715 | 0.03 |
2 | 250(2q37.3) | 0.715 | 0.03 | 12 | 117(12q24.21) | 0.891 | 0.02 | 10 | 109(10q22.3) | 0.592 | 0.05 |
18 | 124(18q23) | 0.625 | 0.04 | 6 | 53(6p21.2) | 0.81 | 0.03 | 4 | 63(4p13) | 0.487 | 0.07 |
12 | 65(12q13.13) | 0.554 | 0.06 | 16 | 87(16q22.2) | 0.737 | 0.03 | 1 | 148(1p12) | 0.418 | 0.08 |
13 | 15(13q12.12) | 0.525 | 0.06 | 6 | 83(6q12) | 0.721 | 0.03 | 6 | 49(6p21.2) | 0.37 | 0.1 |
11 | 136(11q24.3) | 0.406 | 0.09 | 4 | 155(4q32.1) | 0.654 | 0.04 | 19 | 35(19q13.2) | 0.335 | 0.11 |
COVARIATE | |||||||||||
BMI | CM | OBF | |||||||||
Chr | Position | Eq LOD | pval | Chr | Position | Eq LOD | pval | Chr | Position | Eq LOD | pval |
4 | 75(4q13.1) | 1.972 | 0.00258 | 11 | 48(11p13) | 2.004 | 0.00238 | 17 | 94(17q25.1) | 1.746 | 0.00457 |
9 | 90(9q21.33) | 1.583 | 0.00693 | 17 | 94(17q25.1) | 1.788 | 0.00411 | 15 | 101(15q26.2) | 1.7 | 0.00514 |
17 | 38(17p12) | 1.38 | 0.01169 | 10 | 113(10q23.31) | 1.603 | 0.00659 | 5 | 51(5p13.3) | 1.563 | 0.0073 |
15 | 101(15q26.2) | 1.349 | 0.01268 | 6 | 173(6q26) | 1.269 | 0.01561 | 1 | 214(1q31.3) | 1.55 | 0.00754 |
2 | 184(2q32.1) | 1.349 | 0.01269 | 6 | 129(6q23.1) | 1.165 | 0.02053 | 15 | 21(15q13.3) | 1.389 | 0.01143 |
19 | 59(19q13.11) | 1.337 | 0.01309 | 13 | 99(13q33.3) | 1.034 | 0.02907 | 12 | 19(12p13.31) | 1.331 | 0.01331 |
9 | 46(9q21.3) | 1.216 | 0.01795 | 7 | 136(7q32.3) | 0.921 | 0.03942 | 10 | 119(10q23.33) | 1.312 | 0.01395 |
4 | 23(4p15.33) | 1.214 | 0.01807 | 15 | 117(15q26.3) | 0.83 | 0.05059 | 8 | 142(8q24.21) | 1.261 | 0.01595 |
18 | 18(18p11.31) | 1.212 | 0.01816 | 12 | 35(12p12.3) | 0.772 | 0.05928 | 2 | 190(2q32.1) | 1.053 | 0.02764 |
11 | 88(11q14.1) | 1.122 | 0.02304 | 12 | 59(12q12) | 0.766 | 0.06031 | 11 | 48(11p13) | 1.033 | 0.02921 |
AN- and BN-ARP | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
QTL | |||||||||||
OBS | MENAR | ANX | |||||||||
Chr | Position | LOD | pval | Chr | Position | LOD | pval | Chr | Position | LOD | pval |
1 | 208(1q31.3) | 1.984 | 0.00251 | 10 | 35(10p13) | 2.904 | 0.00026 | 1 | 186(1q25.1) | 1.996 | 0.00243 |
7 | 21(7p21.3) | 1.789 | 0.0041 | 4 | 105(4q23) | 2.008 | 0.00235 | 9 | 52(9p21.3) | 1.821 | 0.00378 |
16 | 99(16q23.1) | 1.364 | 0.0122 | 14 | 55(14q22.2) | 1.857 | 0.00345 | 8 | 80(8q13.1) | 1.744 | 0.0046 |
18 | 78(18q21.31) | 1.218 | 0.01787 | 5 | 125(5q23.1) | 1.234 | 0.01713 | 15 | 65(15q24.1) | 1.494 | 0.00872 |
11 | 136(11q24.3) | 1.151 | 0.02132 | 12 | 55(12q12) | 1.133 | 0.02236 | 6 | 131(6q23.1) | 1.367 | 0.01211 |
1 | 98(1p31.1) | 1.092 | 0.02493 | 4 | 13(4p16.1) | 1.112 | 0.02364 | 8 | 0(8p23.3) | 1.121 | 0.02308 |
6 | 177(6q26) | 0.985 | 0.03319 | 10 | 175(10q26.3) | 1.037 | 0.02887 | 6 | 49(6p21.2) | 1.043 | 0.02841 |
12 | 55(12q12) | 0.813 | 0.053 | 20 | 45(20p11.22) | 0.99 | 0.03274 | 13 | 33(13q13.3) | 1.039 | 0.02871 |
10 | 159(10q26.3) | 0.798 | 0.05524 | 12 | 109(12q23.2) | 0.96 | 0.03549 | 14 | 117(14q32.13) | 0.941 | 0.03737 |
8 | 32(8p22) | 0.783 | 0.05758 | 6 | 81(6q12) | 0.92 | 0.03956 | 1 | 76(1p33) | 0.927 | 0.03881 |
COVARIATE | |||||||||||
BMI | CM | OBF | |||||||||
Chr | Position | Eq LOD | pval | Chr | Position | Eq LOD | pval | Chr | Position | Eq LOD | pval |
5 | 2(5p15.33) | 1.709 | 0.00502 | 10 | 96(10q22.1) | 2.258 | 0.00126 | 4 | 2(4p16.1) | 2.631 | 0.0005 |
10 | 38(10p13) | 1.614 | 0.00641 | 16 | 2(16p13.3) | 2.02 | 0.00229 | 10 | 96(10q22.1) | 2.138 | 0.0017 |
14 | 38(14q13.1) | 1.434 | 0.01017 | 17 | 80(17q23.2) | 1.858 | 0.00344 | 3 | 138(3q13.33) | 1.843 | 0.00358 |
10 | 96(10q22.1) | 1.362 | 0.01227 | 6 | 142(6q23.3) | 1.525 | 0.00804 | 10 | 36(10p13) | 1.756 | 0.00446 |
1 | 252(1q42.3) | 1.256 | 0.01616 | 4 | 8(4p16.1) | 1.491 | 0.01109 | 5 | 26(5p15.2) | 1.666 | 0.00561 |
8 | 92(8q21.11) | 1.22 | 0.01779 | 12 | 46(12p11.23) | 1.401 | 0.01346 | 5 | 136(5q31.1) | 1.621 | 0.00629 |
3 | 134(3q13.32) | 1.214 | 0.01807 | 8 | 66(8q11.23) | 1.326 | 0.0193 | 6 | 16(6p25.1) | 1.619 | 0.00632 |
5 | 10(5p15.33) | 1.176 | 0.01993 | 13 | 94(13q33.3) | 1.189 | 0.02907 | 18 | 14(18p11.31) | 1.602 | 0.00661 |
12 | 48(12p11.23) | 1.164 | 0.02059 | 5 | 140(5q31.1) | 1.034 | 0.02926 | 17 | 86(17q24.2) | 1.352 | 0.01258 |
9 | 74(9q21.2) | 1.111 | 0.02369 | 14 | 44(14q21.1) | 1.032 | 0.0298 | 15 | 8(15q12) | 1.263 | 0.01589 |