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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Neuropharmacology. 2008 Aug 8;55(7):1081–1094. doi: 10.1016/j.neuropharm.2008.07.046

Figure 1. Activity-dependent regulation of NR2A and NR2B.

Figure 1

NR2A and NR2B contain distinct signals that control synaptic presentation of NMDARs. Whereas neuronal activity facilitates (+) transcription of NR2A subunit, it attenuates translation of NR2B (-). Neuronal activity also facilitates surface delivery of NR2A and proteasomal degradation of NR2B. (See text for details)