Fig. 5.

Demyelination in PD2 homozygous mice. Low power transmission electron micrograph of a cross-section from a homozygous PD2 optic nerve (A) reveals myelinated axons and astrocytic processes (asterisks), which are seen between the axons, denuded axons and myelin debris. (B) Higher power micrograph of (A) showing that degenerating (arrow) and nude axons (arrowheads) were observed in many areas containing astrocytic processes (asterisks). In areas of variably myelinated axons in optic nerves from homozygous PD2 mice (C,D), denuded axons (arrowheads) and astrocytic processes (asterisk) are seen. Bars, 1 μm.