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The DHDPS from Thermatoga maritima (1O5K, yellow) showing the relationship of pyruvate bound at the active site Lys161 with Ile203 and Asp188. This is overlaid with E. coli DHDPS bound to β-hydroxypyruvate (cyan), showing that one water is conserved (cyan sphere, 2.8 Å from the carboxyl of Asp188) while the other is likely displaced by the presence of β-hydroxypyruvate in the active site.
