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Superposition of Mtb SAHH (violet) with human (red, 1A7A), rat (cyan, 1KY5), and P. falciparum SAHH (yellow, 1V8B). The bound ADO and NAD+ from the Mtb structure are shown for reference. The 37-residue insertion in the Mtb and Plasmodium structures can be seen forming a strand-turn-helix at the surface (upper left, in violet and yellow). α10, αI (insertion), and α11 have been labeled for reference.
