Figure 6.

Active site showing complexes with inhibitors and the substrate. NAD is shown in cyan. Electron density of Shake&wARP (Kantardjieff et al. 2002) omit maps are contoured at the 1 σ level. Ligand molecules were omitted from the model before the map calculation. The blob feature in XTALVIEW (McRee 1999) has been applied to limit the electron density display within 2.0 Å of the ligand and the final figure is rendered with Raster3D (Merritt and Murphy 1994). (A) 3′Keto-aristeromycin (ARI). (B) 2-Fluoroadenosine (2FA). (C) 3-Deazaadenosine (DZA). (D) Ethylthioadenosine (ETA).