Table 5.
All LOD scores of 2.3 and above obtained from entire group and subgroup analysis by sex (n = 336 men, 546 women) and age (n = 498 ≤ 50 yrs, n = 384 > 50 yrs) and LOD scores <2.3 at sites reported previously.
| Chrom Location | Distance (cM) | Geom Pheno. | Peak LOD In AFOS | AFOS population | Flanking Marshfield Marker | Supporting data |
|||
|---|---|---|---|---|---|---|---|---|---|
| Population | Distance | Ref | Candidate genes | ||||||
| 1p35.5 | 46 | NN_ID | 2.57 | ≤ 50 | GATA29A05 | ALKPL | |||
| ATA008 | |||||||||
| NN_OD | M F | 66 | 21 | ||||||
| 1p36 | 43 | NN_Z | 2.36 | ALL | GATA27E01 | BMND 3, MTHFR | |||
| TTTA063 | |||||||||
| 2.43 | M | ||||||||
| NN_OD | M, F | 43 | 32 | ||||||
| 1q23-24 | 96 | S_BR | 2.65 | ≤ 50 | TATC028 | SAC, Hypercalciuria | |||
| AGAT118 | |||||||||
| 2p11.2 | 104 | NN_CSA | 1.92 | > 50 | GATA181G08 | ||||
| GATA69E12 | |||||||||
| S_CSA | M, F | 80 | 32 | ||||||
| S_Z | M, F | 32 | |||||||
| 2p25 | 17 | NN_ID | 2.37 | ≤ 50 | GATA116B01 | ||||
| GAAT1A5 | |||||||||
| 4q11 | 147 | S_Z | 1.94 | ALL | ATA26B08 | ||||
| GATA135C03 | |||||||||
| NN_Z | M, F | 124 | 21 | ||||||
| 5q24–30 | 151 | S_ID | 2.59 | ≤ 50 | AGAT129 | LOX | |||
| GATA51D11 | |||||||||
| 6q22–23 | 170 | NN_CSA | 2.46 | F | GATA184A08 | COL10A1, ENPP-1, WISP3 | |||
| TATC050Z | |||||||||
| S_CSA | M,F | 181 | 32 | ||||||
| 11q22.1 | 104 | S_CSA | 2.3 | F | TCTA025 | ||||
| GATA35 | |||||||||
| 12q24.2 | 96 | S_BR | 2.63 | > 50 | GATA26D02 | ||||
| AGAT114 | |||||||||
| 14q23 | 68 | NN_Z | 2.5 | M | ATA069 | ||||
| GATA169E06 | |||||||||
| 17q11.2-12 | 59 | NN_CSA | 2.16 | ≤ 50 | GGAA9D03 | M, F | 55 | 20 | SOST |
| GATA169F02 | |||||||||
ALKPL (alkaline phosphatase), BMND3 (bone mineral density quantitative locus), MTHFR (methylene tetrahydrofolate reductase), SAC (soluble adenyl cyclase), LOX (lysyl oxidase), COL10A1(type X collagen alpha polypeptide), ENPP-1 (ectonucleotide pyrophosphatase/phosphodiesterase 1, also called alkaline phosphodiesterase 1), WISP3 (wnt-1 inducibel signaling pathway protein 3), SOST (sclerostin)