Figure 2.

Subject A secreted mature gastrin, but her elevated postprandial plasma progastrin level suggested some impairment of processing. (a) Schematic of sequential cleavage and C-terminal modification of gastrin forms. G17 is mature gastrin. (b and c) Plasma progastrin (b) and total amidated gastrin (c) were measured by RIA using antisera L289 and L2, respectively, in the subject (squares) and ten healthy controls (triangles), before and at 20-minute intervals after the start of a high-fat and -carbohydrate test meal. Mature gastrin, G17, was also measured in the subject, using the highly specific antiserum L6 (circles). Control data are mean ± SE.