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Epitope specificity of human anti-IL-15 antibodies. mAb 146B7 (a) and mAb 404E4 (b) were tested for binding to human IL-15 (filled squares), IL-15 mutant Q108S (filled inverted triangles; Gln at residue 108 was replaced by Ser; a mutation in the γ-chain interaction site), and mutant D8SQ108S (filled triangles; Gln at residue 108 was replaced by Ser, and Asp at position 8 was substituted for Ser; mutations in both the β and γ-chain interaction sites of IL-15 with its receptor) (34).
