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. 2003 Nov 15;112(10):1571–1580. doi: 10.1172/JCI18986

Figure 5.

Figure 5

Effect of mAb 146B7 on psoriasis in a psoriasis SCID mouse xenograft model. Quantitative representation of data on the effect of mAb 146B7 shown in Figure 4. SCID mice engrafted with human psoriatic skin were treated i.p. with PBS (n = 15), mAb 146B7 (n = 15), or CsA (n = 16). Skin grafts were harvested after treatment, embedded in paraffin, stained with H&E or for Ki-67 nuclear antigen, and evaluated as indicated for epidermal thickness (a), numbers of inflammatory mononuclear cells in upper dermis (b), numbers of Ki-67+ cycling keratinocytes (c), and grades of parakeratosis (d). Values shown in a–c represent mean ± SEM. Values shown in d represent percentages of mice in each treatment group obtaining the score 0 (white), 1 (light gray), 2 (dark gray), or 3 (black), respectively. The reductions induced by mAb 146B7 compared with PBS were statistically significant for all measured parameters (*P < 0.05, **P < 0.005).