Figure 6.

mAb 146B7 results in a reduction in the number of CD57⁺, CD68⁺, CD4⁺, and CD8⁺ cells in the psoriasis SCID xenograft model. SCID mice engrafted with human psoriatic skin were treated i.p. with PBS (n = 15), mAb 146B7 (n = 15), or with CsA (n = 16). Skin grafts were harvested after treatment, embedded in paraffin, and stained for CD57⁺ NK cells (a), CD68⁺ macrophages (b), CD4⁺ T cells (c), and CD8⁺ T cells (d), and evaluated for number of positively stained cells. Values shown represent mean ± SEM. *P < 0.05 (PBS compared with mAb 146B7).