Skip to main content
. 2003 Nov 15;112(10):1571–1580. doi: 10.1172/JCI18986

Figure 7.

Figure 7

A recent paper by Dubois et al. (40) provided new insight in the mechanism of action of IL-15. The formation of IL-15/IL-15Rα complexes on cell surfaces enables transendosomal recycling of IL-15, leading to persistence of surface-bound IL-15 (a). IL-15/IL-15Rα complexes may induce signaling via IL-15Rβ− and γ-chains expressed on the same cell in cis (b) or expressed on a distinct cell in trans (c). Antibody 146B7 binds at the interaction site of IL-15 with the γ-chain (d) and may effectively block signaling through the γ-chain both in cis and in trans (e).