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. 2008 Jun 20;116(11):1500–1508. doi: 10.1289/ehp.11229

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Effect of Baltimore PM on AHR (A) and BAL protein (B) in naive and OVA-sensitized mice. Values shown are mean ± SE (n = 5–6). (A) AHR, assessed by response to intravenously administered ACh (1 mg/kg), was increased on day 1 and remained elevated at least 7 days after PM exposure. PM stimulated significant AHR in OVA-challenged mice compared with PBS/PBS control A/J mice. Airway responsiveness is expressed as percentage of the time-integrated change in airway pressure over baseline pressure (APTI).

*Significant increase over PBS/PBS control for each time point (p < 0.05). ^#Significant change in response to PBS/OVA group for each time point (p < 0.05). S, synergistic effect between PM and OVA treatment (SI > 1).