TABLE I.
Top 10 ranked genes for models which do and do not account for covariates
|
P-value rank (unadjusted P-value)
|
||||||
|---|---|---|---|---|---|---|
| Affymetrix Hu95Av2 probe set | Gene | Gene ontology molecular function(s) | Accounting for smoking status and pH | Not accounting for smoking status and pH | Accounting for smoking status, pH, age and gender | Accounting for smoking status, pH and random covariate |
| 1495_at | Latent transforming growth factor β binding protein 1 | Calcium ion binding/growth factor binding/transforming growth factor β receptor activity/protein binding | 1 (0.0007) | 20 (0.008) | 6 (0.0003) | 1 (0.0001) |
| 41863_at | Hypothetical protein LOC138046 | Nucleotide binding/RNA binding | 2 (0.0007) | 28 (0.009) | 2 (0.0001) | 4 (0.0002) |
| 327_f_at | Ribosomal protein S20 | RNA binding/structural constituent of ribosome | 3 (0.0007) | 35 (0.010) | 4 (0.0002) | 2 (0.0001) |
| 41666_at | Heat shock 70kDa protein 12A | ATP binding/nucleotide binding | 4 (0.0007) | 350 (0.064) | 10 (0.0004) | 3 (0.0001) |
| 32838_at | Myosin, heavy polypeptide 10, non-muscle | Actin binding /ATP binding/ calmodulin binding/ motor activity/nucleotide binding | 5 (0.0007) | 7 (0.004) | 5 (0.0002) | 6 (0.0003) |
| 41474_at | Kinesin heavy chain member 2 | ATP binding/microtubule motor activity/motor activity/ nucleotide binding | 6 (0.0007) | 543 (0.094) | 17 (0.0009) | 8 (0.0004) |
| 39173_at | Fibrillarin | Protein binding/RNA binding | 7 (0.001) | 107 (0.027) | 18 (0.0009) | 7 (0.0003) |
| 37508_f_at | Formin binding protein 3 | Protein binding | 8 (0.001) | 17 (0.007) | 28 (0.0015) | 10 (0.0005) |
| 39549_at | Neuronal PAS domain protein 2 | DNA binding/signal transducer activity/transcription factor activity/transcription regulator activity | 9 (0.002) | 31 (0.008) | 22 (0.0013) | 5 (0.0002) |
| 39338_at | S100 calcium binding protein A10 | Calcium ion binding | 10 (0.002) | 14 (0.005) | 11 (0.0004) | 20 (0.001) |