Table 2.
Allele and genotype frequencies of DBH -1021C>T (rs1611115)
| Series | Affection status | Samples No. | Genotype CC No. (%) | Genotype CT No. (%) | Genotype TT No. (%) | C allele No. (%) | T allele No. (%) | Odds ratio (95% CI) | p-value |
|---|---|---|---|---|---|---|---|---|---|
| US | Patient | 224 | 128 (60) | 71 (33) | 15 (7) | 327 (76) | 101 (24) | 0.94 (0.69–1.28) | 0.70 |
| Control | 224 | 125 (57) | 85 (38) | 11 (5) | 335 (76) | 107 (24) | |||
| Ireland | Patient | 74 | 116 (67) | 49 (28) | 8 (5) | 281 (81) | 65 (19) | 0.84 (0.59–1.19) | 0.33 |
| Control | 174 | 107 (62) | 55 (32) | 10 (6) | 269 (78) | 75 (22) | |||
| Norway | Patient | 538 | 368 (69) | 150 (28) | 13 (2) | 886 (83) | 176 (17) | 0.81 (0.67–0.98) | 0.03 |
| Control | 1138 | 731 (65) | 344 (31) | 48 (4) | 1806 (80) | 440 (20) | |||
| Poland | Patient | 101 | 56 (55) | 37 (37) | 8 (8) | 149 (74) | 53 (26) | 2.01 (1.24–3.25) | 0.01 |
| Control | 123 | 85 (69) | 35 (28) | 3 (2) | 205 (83) | 41 (17) | |||
|
| |||||||||
| Combined | Patient | 1037 | 668 (66) | 307 (30) | 44 (4) | 1643 (81) | 395 (19) | 0.91 (0.79–1.04) | 0.16 |
| Control | 1659 | 1048 (64) | 519 (32) | 72 (4) | 2615 (80) | 663 (20) | |||
- For the matched US and Irish series, estimated odds ratios and p-values result from single variable conditional logistic regression models. For the Norwegian, Polish, and combined series, estimated odds ratios and p-values result from logistic regression models adjusted for age, sex, and series (combined series only). Under an additive model odds ratios correspond an increase of one “T” allele. Total sample sizes given for each series do not account for genotyping failure, which occurred in <2% of samples.