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. Author manuscript; available in PMC: 2008 Dec 2.
Published in final edited form as: Mol Ther. 2007 Jun 12;15(10):1812–1819. doi: 10.1038/sj.mt.6300228

Figure 2. Photomicrographs depicting the histopathology of rat pancreas.

Figure 2

(a) Pancreas from a rat after sham surgery. (b-d) Pancreas from animals with dibutyltin dichloride (DBTC)-induced pancreatitis treated with the following: (b) vehicle as vector control, (c) HSV-β-gal, or (d) HSV-ENK. Note the inflammatory cell infiltration, acinar cell atrophy, widened inter- and intra-lobular ducts, tissue edema and extensive periductal fibrosis seen in DTBC-induced pancreatitis with vehicle or HSV-β-gal applications, compared to reduced inflammatory cell infiltration and to preservation of pancreatic tissue architecture in the DTBC and HSV-ENK treated rats. ENK, enkephalin; H&E, hemotoxylin and eosin stain; HSV, herpes simplex virus.