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Role of NM II-A in collagen phagocytosis. Initial collagen binding to α2β1-integrin (step 1) promotes NM II-A recruitment (step 2) and MLCK-induced phosphorylation of MLC (step 3). MLC phosphorylation promotes NM II-A filament assembly (step 4) and Rap1 binding (step 5). This process increases Rap1-mediated affinity of β1-integrins (step 6), thereby increasing collagen binding in early steps of collagen phagocytosis.
