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Amelioration of the effects of Shh overexpression by zGRK2/3 knockdown. (A and B) Level of nkx2.2 expression in control embryos and in zGRK2/3 morphants. (C) Embryos injected with capped shh mRNA. (D) Knockdown of zGRK2/3 is able to normalize unrestrained Hh signaling to control levels. All pictures: 24 hpf, anterior to the left, dorsal to the top.
