Table 1. c-myc/IgH chromosomal translocations in IL6tg mice.
Transloctiona | IDb | Genotype | c-mycc | Jncd | IgHe |
IgHμ | A1 | AID+/+ | AAACAGCTCGAGGAaCTCTTTTCAG | G | GCTGGGGTGAGCTGAGCTGAGCTGG |
IgHμ | A2 | AID+/+ | CTTTCCTCTGTCATCTTGACAAGTC | CTGAGCTGGGTGAGCTGAGCTGAAC | |
IgHμ | A3 | AID+/+ | GCCTTCAAACAGCTCGAGGAGCTCT | CTGGATTGAACTGAGCTGTGTGAgC | |
IgHμ | A4-1 | AID+/+ | AATCCAGCCTTCAAACAGCTCGAGG | AGC | CCTGCCTGCCTTAAGAGTAGCAACA |
IgHμ | A4-2 | AID+/+ | GGACGGGTTGCGATCGCCGCtGGGG | TGAGCTGGGGTGAGCTGAGCTGGGG | |
IgHμ | A10 | AID+/+ | TTGGGGAGAGTGGGCGGCAGGCTCG | TGGGATGAGGTAGGCTGGGATGAGC | |
IgHμ | A11 | AID+/+ | AGAGCTGATCGCGGGCAGAGGCAGA | G | GCTGGCCTGGCTGATGAGCTAAGCT |
IgHμ | A13 | AID+/+ | AGCCTGGGGAGTCCTGTCCTGGCTC | GC | TGGGGTGAGCTGAGCTGAGCTGAGC |
IgHμ | A15 | AID+/+ | TAAAAGGCTCAGGGACGGGTTGCGA | GAGCTGAGCTGGGGTGAGCTGAGCT | |
IgHμ | A17 | AID+/+ | ACTCTTGAGAAAAGTGTCAAAAaCA | C | TGGGGTGAGCTGAGCTGAGCTGAGC |
IgHμ | B2 | AID+/− | CTAGCAATTCAGGGGCGCGAGGCAT | A | GCTGAGCTGAGCTGAGCTGGGTGAG |
IgHμ | B5 | AID+/− | CTCTTGAGAAAAGTGTCAAAAGtAC | A | aCTGAGCTGAGCTGAGCTGGGGTGA |
IgHμ | B6 | AID+/− | CACTCCAGAGCTGCCTTCTTAGGTC | GC | TGAGCTGGGGTGAGCTGGGCTGAGC |
IgHμ | B7 | AID+/− | AAGAACACAGGGAAAGACCACCAGA | GCTGGGGTGAGCTGAGCTGAGCTGG | |
IgHμ | B9 | AID+/− | TCAAAATGCATCCCGGTTTTTCCCT | T | GGGCTGAGCTGGGTTGGGAGACCAT |
IgHμ | B10 | AID+/− | CTCTTTTCAGGAGAGCTGATCGCGG | GC | TGGGGTGAGgTGaGCTGAGCTGGGG |
IgHμ | B11 | AID+/− | AAAGCACAGGAATGGAAGAAAGACT | G | CTGAGCTGGGGTGAGCTGAGCTGAG |
IgHμ | B13 | AID+/− | CAAGAATGTCCAACCGGCCGGGTCA | G | AGCTGAGCTGGGGTGAGCTGAGCTG |
IgHα | A11 | AID+/+ | ATCTTGACAAGTCGCTCTACCCCGA | CT | GAGCTAGACTTANGGTGNAATGGGC |
IgHα | A12 | AID+/+ | GGGATTGGCGGGCGGGACGCACCTC | C | TAGgCTGGGGTGAATTAGCATGACT |
IgHα | A15 | AID+/+ | AACCGGCCGCTACATTCNAGACGCA | G | CTGGGCTGAGCTGGAATGAGCTGGG |
Proximal (IgHμ) or distal (IgHα) c-myc/IgH chromosomal translocation.
Mouse identification as referred to in figure 2b.
c-myc sequence adjacent to translocation junction. Mutations are shown in lowercase.
Microhomology at junctions (overlapping sequences that cannot be assigned to a single sequence, c-myc, or Ig).
IgH Reverse complementary sequence adjacent to translocation junction. Mutations are shown in lowercase.