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. 2008 Dec 11;3(12):e3932. doi: 10.1371/journal.pone.0003932

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Kidder et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Relationship between Stat3 and c-Myc bound genes with Nanog, Oct4, Eed, and Suz12 bound genes. GSEA analysis of (B) Stat3 target genes, (C) Stat3 target genes with AcH3 marks, (D) Stat3/Nanog target genes, (E) Stat3 target genes with H3K4/27me3 marks, and (F) Stat3/Eed target genes in ES cells and differentiated EBs. GSEA analysis of (G) c-Myc target genes, (H) c-Myc target genes with AcH3 marks, and (I) c-Myc/Nanog target genes in ES cells and differentiated EBs. Red indicates active genes in ES cells and blue indicates active genes in EBs. (J) Relationship between Stat3 and c-Myc target genes, Oct4/Sox2/Nanog target genes, polycomb repressive complex 1 (Rnf2/Phc1), polycomb repressive complex 2 (Suz12/Eed), and genes with histone marks H3K4/27me3. The number of genes co-bound by Stat3 or c-Myc is displayed.