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. 2008 Dec 26;4(12):e1000250. doi: 10.1371/journal.pcbi.1000250

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Nowlan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Up is distal, down is proximal. tt: tibiotarsus, mt: metatarsals. The approximate location of the bone collar is indicated with a green line. Ihh is expressed in the hypertrophic (HH30) and pre-hypertrophic (HH30–32) zones (black arrowheads), elevated expression at the periphery highlighted with white arrowheads. Scale bars 1 mm.