Table 2.
Top 10 pairs of multi-protein complexes that present 'between' synthetic genetic interactions
| Essential genes | |||||||
| Complex 1/complex 2 | P-values (adjusted) | Odds | Expected | Interact | Tested | Complex 1 | Complex 2 |
| Condensed kinetochore [GO:0000778]/prefoldin [GO:0016272] | 5.54e-86 | 350.66 | 0.50 | 49 | 68 | 19 | 0 |
| Outer kinetochore [MIPS-270.20]/prefoldin [GO:0016272] | 1.51e-72 | Inf | 0.26 | 35 | 35 | 12 | 0 |
| Prefoldin [GO:0016272]/SWR1 [GO:0000812] | 7.05e-50 | 326.96 | 0.30 | 29 | 41 | 0 | 5 |
| Ctf3 [GO:0016272]/prefoldin [GO:0005868] | 1.61e-36 | 674.97 | 0.18 | 20 | 24 | 0 | 0 |
| Prefoldin [MIPS-270.20.20]/cytoplasmic dynein [GO:0016272] | 7.23e-30 | Inf | 0.11 | 15 | 15 | 0 | 0 |
| Ctf18 RFC-like [GO:0016272]/prefoldin [GO:0005869] | 5.78e-27 | 674. 13 | 0.13 | 15 | 18 | 0 | 0 |
| Prefoldin [GO:0031390]/Dynactin [GO:0016272] | 5.78e-27 | 674. 13 | 0.13 | 15 | 18 | 4 | 0 |
| Dynein motorproteins [MIPS-140.30.30.20]/prefoldin [GO:0016272] | 5.78e-27 | 674. 13 | 0.13 | 15 | 18 | 0 | 0 |
| Dynactin [MIPS-140.30.30.30]/prefoldin [GO:0016272] | 5.78e-27 | 674. 13 | 0.13 | 15 | 18 | 0 | 0 |
| Kinetochore [GO:0000776]/condensed kinetochore [GO:0000778] | 3.24e-25 | 85.47 | 0.36 | 19 | 49 | 7 | 19 |
Top 10 pairs of multi-protein complexes that present between synthetic genetic interactions in Tong et al. [10]. P-values (adjusted), Bonferroni adjusted P-value of the hypergeometric test; Odds, odds ratios; Expected, expected number of synthetic genetic interactions between multi-protein complexes; Interact, number of synthetic genetic interactions observed (positive edges); Tested, number of interactions (edges) tested; Essential genes, number of essential genes in multi-protein complexes 1 and 2, respectively. Note that when all the tested interactions are synthetic genetic interactions (tested = interact) the odds ratios are infinite (Inf).