Table 2.
Comparison of comorbidities of the patients in studies by Rivers and colleagues [2] and Sprung and colleagues (CORTICUS) [23]
| Rivers et al. | Sprung et al. | ||
| (n = 263) | (n = 499) | Chi-square test | |
| Caucasian (%) | Not reported | 93 | |
| Age (years) | 65.7 | 63 | |
| Male/Female (%) | 50.6/49.4 | 66.5/33.5 | 0.0000 |
| Hypertension (%) | 67.3 | 37.7a | 0.0000 |
| Coronary artery disease (%) | 25.0 | 16.9a | 0.0080 |
| Congestive heart failure (%) | 33.4 | 6.0a | 0.0000 |
| Diabetes (%) | 31.4 | 21.6a | 0.0030 |
| Chronic obstructive pulmonary disease (%) | 15.7 | 11.3a | 0.0900 |
| Chronic renal failure (%) | 21.7 | 8.7a | 0.0000 |
| Liver disease (%) | 23.3 | 8.1a | 0.0000 |
| Neurologic disease (%) | 33.0 | 11.7a | 0.0000 |
| Cancer (%) | 11.4 | 16.9a | 0.0580 |
| Alcohol use (%) | 38.6 | Not reported |
an = 496. CORTICUS, Corticosteroid Therapy of Septic Shock.