Figure 3.

Forest plot of the overall meta-analysis results in randomized clinical trials and observational studies. Changes after 12 months of therapy versus baseline in (a) the forced vital capacity (FVC) and (b) the diffusing capacity for carbon monoxide (DLCO), pooled from the cyclophosphamide (CYC) arms of randomized clinical trials and observational studies. See Tables 2 and 3 for study details. SE, standard error; CI, confidence interval; Chi², chi-squared; df, degree of freedom; I², I-squared; Z, Z value; High Pred, high dose of prednisone; Low Pred, low dose of prednisone; Oral, oral administration; Pulse, intravenous administration; RCT, randomized clinical trial; Mean difference, weighted mean difference; Random, random-effects model.