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. 2008 Dec 1;183(5):769–776. doi: 10.1083/jcb.200808097

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© 2008 Mortusewicz et al.

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Figure 2. — PC4 accumulates at laser-induced DNA damage sites. Widefield fluorescence images of mouse C2C12 and human HeLa cells are shown. Fixation and immunostaining was performed ∼5 min after laser microirradiation. Arrowheads mark the sites of irradiation. Laser microirradiation results in local generation of DNA damage (A, B, and D) detected by antibodies against γH2AX and PAR, respectively. Endogenous PC4 accumulates at DNA damage sites in mouse (A and B) and human (D) cells and colocalizes with PCNA (C and E). Bar, 5 μm.