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. 2008 Dec 1;183(5):805–818. doi: 10.1083/jcb.200806038

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© 2008 Erhardt et al.

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Figure 5. — Defects in centromere assembly after CYCA and RCA1 depletion do not result from overreplication. (A) Geminin RNAi causes overreplication without loss of CID or CENP-C from centromeres. Fluorescence images of DNA, CID, and CENP-C in control cells and cells depleted of geminin. Large nuclei are indicative of overreplication in geminin-depleted cells without disruption of CID or CENP-C localization. The graph shows quantification of CID and CENP-C levels at centromeres with and without geminin depletion (n = 4; error bars represent SEM). (B) Endoreduplication naturally occurs in Drosophila embryos and larvae. CID (red) is present at the centromere in embryonic cells with endoreduplicated chromosomes stained for histone H3Ser10 phosphorylation (green). Bars: (A) 15 μm; (B) 5 μm.