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. 2008 Dec 1;183(5):909–921. doi: 10.1083/jcb.200808034

Figure 2.

Figure 2.

The hyperpolarizing afterpotential is K+ dependent. (A and B) Representative optic nerve CAPs from wild-type (A) and Claudin 11–null mice (B) recorded for several concentrations of KCl in the bath solution (n = 5). ACSF solution normally contains 3 mM KCl. The hyperpolarization that follows the CAPs from −/− mice in ACSF is increased in low KCl (1 mM) and, reciprocally, decreased in high KCl (6 and 9 mM). In contrast, CAPs from +/+ mice are not affected by extracellular KCl concentrations between 1 and 6 mM. Gray shading represents the CAPs at 3 mM KCl.