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. 2008 Dec 1;183(5):909–921. doi: 10.1083/jcb.200808034

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Figure 3. — Effects of K⁺ channel blockers on optic nerves from Claudin 11–null mice. (A) Representative CAPs from wild-type (top) and Claudin 11–null (bottom) mice treated with DTX or 4-AP in the bath medium. DTX broadens the CAPs only in −/− optic nerves. (B) Fluorescence image from a 10-μm frozen section of wild-type mouse optic nerve incubated with 6-FAM-SHK. The toxin has access to and labels juxtaparanodal K_v1.1 and K_v1.2 channels under the myelin sheaths in most axons (arrowheads). Nodes of Ranvier are unlabeled. Bar, 20 μm. (C) DTX has little effect on the CVs for each component (mean ± SD) in wild-type (+/+; n = 5) and Claudin 11–null (−/−; n = 4) mice. (D) Western blotting for K_v1.1 and K_v1.2 in single optic nerves show similar expression levels in +/+ and −/− mice after adjusting for protein loading (bottom; Coomassie blue R250–stained duplicate gels).