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PSI-6130 and NM107 clear the HCV replicon. Cells harboring the stable HCV replicon were treated with 10× the EC50 of PSI-6130, NM107, or NNI-1 in the absence of G418 for 29 days (clearance phase). The inhibitors were then removed, and G418 was added for 14 days (rebound phase). HCV replicon levels were monitored using qPCR during the clearance and rebound phases.
