TABLE 1.

PSI-6130 is a potent inhibitor of the GT-1b and GT-1a HCV replicon^a

Compound	GT-1b (Con1) (μM [mean ± SEM])					GT-1a (H77) EC50 (transient Firefly luciferase) (μM [mean ± SEM])
	EC50 (stable qPCR)	EC50 (stable Renilla luciferase)	EC50 (transient Firefly luciferase)	qPCR EC50 (40% human serum)	CC50c WST-1
PSI-6130	0.46 ± 0.13	0.61 ± 0.04	0.51 ± 0.04	0.51 ± 0.18	>300	0.30 ± 0.04
NM107	1.13 ± 0.34	1.51 ± 0.17	1.1 ± 0.07	1.69 ± 0.44	>100	NDb
R7128	0.32 ± 0.09	0.70 ± 0.16	0.89 ± 0.07	ND	>100	ND

^aSEM values represent standard errors of the means of the results of a minimum of three independent experiments.

^bND, not determined.

^cCC₅₀, 50% cytotoxicity concentration.