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PSI-6130 activity against WT and S282T stable HCV replicon
| Compound | qPCR EC50 (μM [mean ± SEMa])
|
EC50 fold shiftb | |
|---|---|---|---|
| WT | S282T | ||
| PSI-6130 | 0.31 ± 0.08 | 0.75 ± 0.22 | 2.4 |
| R7128 | 0.32 ± 0.09 | 1.08 ± 0.03 | 3.4 |
| NM107 | 1.55 ± 0.31 | 26.31 ± 3.77 | 17.0 |
| NNI-1 | 0.31 ± 0.04 | 0.22 ± 0.03 | 0.8 |
SEM values represent standard errors of the means of the results of a minimum of three independent experiments.
Shift calculated as EC50 for S282T mutants divided by EC50 for the WT.
