TABLE 8.

Lack of cross-resistance between PSI-6130 and R1479 in the transient replicon assay

Replicon mutant	Replication capacity (% of WT)	Transient replicon EC50 (mean ± SEM [μM])d
		PSI-6130	R1479
WT	100a	0.82 ± 0.04	1.90 ± 0.26b
S96T	4a	0.42 ± 0.00	8.2 ± 0.66a
S282T	15	2.51 ± 0.29	0.53 ± 0.1b
S96T/S282T	0.6	NDc	NDc

^aFrom Le Pogam et al. (23).

^bFrom Klumpp et al. (22).

^cND, EC₅₀ values could not be determined due to low replication capacity.

^dSEM values represent standard errors of the means of the results of three to five independent experiments.