TABLE 3.
ITMN-191/peginterferon alfa-2a CIsa
| ITMN-191 (nM)/peginterferon alfa-2a (pg/ml) ratio | CIb
|
||
|---|---|---|---|
| EC50 | EC75 | EC90 | |
| 3.7/22,000 | 0.45 ± 0.23 | 0.45 ± 0.17 | 0.45 ± 0.09 |
| 11/22,000 | 0.36 ± 0.13 | 0.36 ± 0.10 | 0.36 ± 0.07 |
| 33/22,000 | 0.6 ± 0.53 | 0.57 ± 0.45 | 0.56 ± 0.36 |
| 11/2,444 | 0.34 ± 0.11 | 0.36 ± 0.02 | 0.4 ± 0.11 |
| 100/7,333 | 0.43 ± 0.13 | 0.47 ± 0.09 | 0.53 ± 0.05 |
| 100/2,444 | 0.68 ± 0.40 | 0.71 ± 0.25 | 0.75 ± 0.06 |
| 100/815 | 0.39 ± 0.26 | 0.57 ± 0.20 | 0.84 ± 0.08 |
a
Using NPTII enzyme-linked immunosorbent assay and CalcSyn (2), the EC50s for ITMN-191 and peginterferon alfa-2a as single agents were 4.4 nM and 1,752 pg/ml, respectively.
b
Values are reported as mean ± standard deviation based on a minimum of three independent experiments.