Fig. 2.

Validation of the 50-gene predictor of colon cancer recurrence. (A) Independent validation of the prognostic model: the scatter plot compares individual and mean Recurrence Scores for the MEXP-1224 cohort (n = 55) grouped by actual recurrence (P = 0.002, t test). (B) Blinded validation of the prognostic model: the scatter plot demonstrates a comparison of mean Recurrence Scores for the cohort (n = 73) grouped by actual recurrence (P = 0.007, t test; 90% sensitivity). (C) The Kaplan–Meier survival analysis demonstrates time to recurrence for the two groups: the blue curve represents those patients predicted to remain disease-free by the model, and the red curve represents those predicted to have recurrence.