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. 2008 Dec 3;14:2190–2203.

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cannabidiol reduces oxidative and nitrative stresses in the uveitic retina. A: Cannabidiol (CBD) reduces reactive oxygen species (ROS) in the retinas of uveitic rats as represented by DCF fluorescence in rat retina. Representative image shows the fluorescence distribution in different retinal layers (magnification ×100). Abbreviations: Ganglion cell layer (GCL); inner nuclear layer (INL); outer nuclear layer (ONL). B: Morphometric analysis of fluorescence intensity in serial sections of rat eyes shows that uveitic rats had a significant increase in fluorescence (1.5-fold) compared with controls. Treatment with CBD (5 mg/kg) inhibited ROS formation in uveitic rats. Data shown is the mean±SEM of 4-5 animals in each group (asterisk represents that it is significantly different when compared with the controls at p<0.05). C: CBD reduces nitrotyrosine in the retina of uveitic rats. A representative image shows the nitrotyrosine distribution mainly in the retinal plexiform layers and outer segments (magnification ×200). D: Morphometric analysis of fluorescence intensity in serial sections of rat eyes showing that uveitic rats had a significant increase in fluorescence (2.8-fold) compared with controls. Treatment with CBD (5 mg/kg) inhibited nitrotyrosine formation in the uveitic rats. Data shown is the mean±SEM of 6 animals in each group (asterisk represents that it is significantly different when compared with the controls at p<0.05).